產(chǎn)品描述

在生命科學、基礎醫(yī)學及高原生理等研究領(lǐng)域，精確模擬低氧環(huán)境對于探究缺氧對動物機體的影響至關(guān)重要。低氧工作站正是為此類嚴謹動物實驗而設計的核心設備。

不同于普通低氧實驗箱在操作時必須開箱破壞環(huán)境，低氧工作站通過其全密閉結(jié)構(gòu)和內(nèi)置操作手套，實現(xiàn)了革命性的突破。研究者無需打開主腔室，即可通過氣密手套在持續(xù)、穩(wěn)定維持目標低氧水平（如1%-21% O?可調(diào)）的環(huán)境下，對箱內(nèi)動物進行各項操作，包括：

?日常照料：安全地進行喂食、飲水更換，確保動物長期實驗中的基本生存需求。

?實驗干預：執(zhí)行精準的給藥、注射、手術(shù)或生理參數(shù)監(jiān)測（如體溫、心率）。

?行為觀察：在恒定低氧條件下進行動物行為學實驗，減少環(huán)境波動干擾。

?原位采樣：直接在低氧環(huán)境中采集血液、組織等樣本，很大程度避免樣本暴露于常氧環(huán)境導致的氧化應激或代謝狀態(tài)改變，保障后續(xù)分析數(shù)據(jù)的真實性。

?設備操作：放置或操作小型實驗儀器（如微型跑步機、攝像頭）。

核心優(yōu)勢

1、環(huán)境穩(wěn)定性：操作過程“零中斷"低氧環(huán)境，氧氣濃度波動極?。ㄍǔ?lt;±0.1%），為慢性、長期低氧暴露實驗（數(shù)天至數(shù)月）提供持續(xù)、可靠的低氧條件，消除因頻繁開箱導致的濃度回升與恢復延遲問題。

2、操作便利性與連續(xù)性：無需等待環(huán)境恢復，可隨時、頻繁地進行實驗操作，極大提升實驗效率和靈活性。

3、減少動物應激：密閉操作減少了光線、噪音和人員活動對動物的直接干擾，有助于獲得更接近自然狀態(tài)的生理反應數(shù)據(jù)。

4、保障樣本真實性：低氧環(huán)境下的原位采樣和處理，是研究缺氧相關(guān)生物標志物、基因表達和代謝產(chǎn)物的關(guān)鍵保障，避免取樣后氧化造成的假象。

5、集成環(huán)境控制（可選）：高級型號可集成精確的溫濕度控制系統(tǒng)及CO?清除裝置，為動物提供更舒適、生理狀態(tài)更穩(wěn)定的實驗環(huán)境。

6、潔凈度與安全性：密閉設計結(jié)合高效過濾系統(tǒng)（HEPA/ULPA），可有效控制微生物污染；同時為操作者提供物理屏障，隔絕潛在過敏原或?qū)嶒炐杂泻ξ镔|(zhì)。

應用場景

低氧工作站是進行高原適應機制研究、缺血性疾病模型、低氧相關(guān)腫瘤研究、低氧與代謝疾病的研究、低氧與心血管疾病的研究、圍生期缺血缺氧性腦損傷以及任何要求在穩(wěn)定低氧環(huán)境下進行活體操作或原位取樣的動物實驗的理想平臺。它克服了傳統(tǒng)低氧箱的核心局限，為獲得嚴謹、可重復的高質(zhì)量科研數(shù)據(jù)奠定了堅實的基礎。

技術(shù)參數(shù)

1. 為動物低氧實驗模型的建立提供穩(wěn)定的低氧環(huán)境

2. 按照設定氣體濃度自動配比氣體，維持恒定的氧氣濃度環(huán)境。無需在箱體外混合比例氣體，實驗氧濃度的準確，節(jié)省氣源

3. 觸摸屏控制，人性化界面，操作簡單

4. 監(jiān)測參數(shù)：溫度、濕度、氧氣濃度、二氧化碳濃度

5. 控制精度：±0.1%

6. 非色散紅外（NDIR）二氧化碳傳感器，測量范圍：0～5000ppm

7. 進口電化學氧氣濃度檢測器，測量范圍：0-25%vol（可選配0.1-99.0%），線性度好，檢測準確、使用壽命長。具有溫度補償機制

8. 溫度檢測：進口高精度溫度傳感器

9. 氧氣濃度變化動態(tài)曲線，直觀了解氧氣濃度變化的過程

10. 內(nèi)置紫外滅菌燈，可定時滅菌

11. 具有定時功能，實驗完成，自動恢復常氧狀態(tài)，并伴有聲音提示

12. 氧氣濃度自動校準：通過控制器對傳感器快速校準

13.氣體混合及循環(huán)機制，保證箱體內(nèi)氣體濃度的均一

14. 高性能電磁閥，性能穩(wěn)定，超長壽命

15. 前面板可徒手拆卸，便于放置設備

可選配功能

1、溫度濕度控制功能，控溫范圍：室溫+3~45℃（可選4~45℃），調(diào)節(jié)精度0.1℃；濕度40~85%RH

2、遠程監(jiān)控：可通過電腦、手機遠程監(jiān)控實驗運行狀態(tài)，具有可夜視紅外攝像頭

3、二氧化碳吸附裝置

4、二氧化碳濃度控制功能，可設定目標濃度，控制范圍：0-20.0%，其他范圍可選

型號選擇

相關(guān)文獻

[1] Drekolia M K, Mettner J, Wang D, et al. Cystine import and oxidative catabolism fuel vascular growth and repair via nutrient-responsive histone acetylation[J]. Cell Metabolism (IF 30.9), 2025.

[2] Wu L W, Chen M, Jiang C Y, et al. Inactivation of AXL in Cardiac Fibroblasts Alleviates Right Ventricular Remodeling in Pulmonary Hypertension[J]. Advanced Science (IF 14.1), 2025: e08995.

[3] Lei R, Gu M, Li J, et al. Lipoic acid/trometamol assembled hydrogel as injectable bandage for hypoxic wound healing at high altitude[J]. Chemical Engineering Journal (IF 13.4), 2024, 489: 151499.

[4] Li Z, Li H, Qiao W, et al. Multi-omics dissection of high TWAS-active endothelial pathogenesis in pulmonary arterial hypertension: bridging single-cell heterogeneity, machine learning-driven biomarkers, and developmental reprogramming[J]. International Journal of Surgery (IF 10.1), 10.1097.

[5] Pei Y, Huang L, Wang T, et al. Bone marrow mesenchymal stem cells loaded into hydrogel/nanofiber composite scaffolds ameliorate ischemic brain injury[J]. Materials Today Advances (IF 10), 2023, 17: 100349.

[6] Wang Q, Liu J, Li R, et al. Macrophage κ-opioid receptor inhibits hypoxic pulmonary hypertension progression and right heart dysfunction via an SCD1-dependent anti-inflammatory response[J]. Genes & Diseases (IF 9.4), 2025: 101604.

[7] Wang Y, Zhang R, Chen Q, et al. PPARγ Agonist Pioglitazone Prevents Hypoxia-induced Cardiac Dysfunction by Reprogramming Glucose Metabolism[J]. International Journal of Biological Sciences, 2024, 20(11): 4297.

[8] Wang Y, Shen P, Wu Z, et al. Plasma Proteomic Profiling Reveals ITGA2B as a key regulator of heart health in high-altitude settlers[J]. Genomics, Proteomics & Bioinformatics, 2025: qzaf030.

[9] Lan Y, Zhao S, Song Y, et al. Physicochemical properties of selenized quinoa protein hydrolysate and its regulatory effects on neuroinflammation and gut microbiota in hypoxic mice[J]. Journal of Future Foods, 2025.

[10] Pan Z, Yao Y, Liu X, et al. Nr1d1 inhibition mitigates intermittent hypoxia-induced pulmonary hypertension via Dusp1-mediated Erk1/2 deactivation and mitochondrial fission attenuation[J]. Cell Death Discovery, 2024, 10(1): 459.

[11] Zhou Y, Ni Z, Liu J, et al. Gut Microbiota‐Associated Metabolites Affected the Susceptibility to Heart Health Abnormality in Young Migrants at High‐Altitude: Gut Microbiota and Associated Metabolites Impart Heart Health in Plateau[C]//Exploration. 2025: 20240332.

[12] Li C, Zhao Z, Jin J, et al. NLRP3-GSDMD-dependent IL-1β Secretion from Microglia Mediates Learning and Memory Impairment in a Chronic Intermittent Hypoxia-induced Mouse Model[J]. Neuroscience, 2024, 539: 51-65.

[13] Yang W, Li M, Ding J, et al. High-altitude hypoxia exposure inhibits erythrophagocytosis by inducing macrophage ferroptosis in the spleen[J]. Elife, 2024, 12: RP87496.

[14] You Z, Huang Q, Zeng L, et al. Rab26 promotes hypoxia-induced hyperproliferation of PASMCs by modulating the AT1R-STAT3-YAP axis[J]. Cellular and Molecular Life Sciences, 2025, 82(1): 1-16.

[15] Pei C, Shen Z, Wu Y, et al. Eleutheroside B Pretreatment Attenuates Hypobaric Hypoxia‐Induced High‐Altitude Pulmonary Edema by Regulating Autophagic Flux via the AMPK/mTOR Pathway[J]. Phytotherapy Research, 2024, 38(12): 5657-5671.

[16] Duan H, Han Y, Zhang H, et al. Eleutheroside B Ameliorates Cardiomyocytes Necroptosis in High-Altitude-Induced Myocardial Injury via Nrf2/HO-1 Signaling Pathway[J]. Antioxidants, 2025, 14(2): 190.

[17] Song J, Zheng J, Li Z, et al. Sulfur dioxide inhibits mast cell degranulation by sulphenylation of galectin-9 at cysteine 74[J]. Frontiers in Immunology, 2024, 15: 1369326.

[18] Jia N, Shen Z, Zhao S, et al. Eleutheroside E from pre-treatment of Acanthopanax senticosus (Rupr. etMaxim.) Harms ameliorates high-altitude-induced heart injury by regulating NLRP3 inflammasome-mediated pyroptosis via NLRP3/caspase-1 pathway[J]. International Immunopharmacology, 2023, 121: 110423.

[19] Huang Q, Han X, Li J, et al. Intranasal Administration of Acetaminophen-Loaded Poly (lactic-co-glycolic acid) Nanoparticles Increases Pain Threshold in Mice Rapidly Entering High Altitudes[J]. Pharmaceutics, 2025, 17(3): 341.

[20] Wu Y, Tang Z, Du S, et al. Oral quercetin nanoparticles in hydrogel microspheres alleviate high-altitude sleep disturbance based on the gut-brain axis[J]. International Journal of Pharmaceutics, 2024, 658: 124225.

[21] Zhou Z, Zhao Q, Huang Y, et al. Berberine ameliorates chronic intermittent hypoxia‐induced cardiac remodelling by preserving mitochondrial function, role of SIRT6 signalling[J]. Journal of Cellular and Molecular Medicine, 2024, 28(12): e18407.

[22] Shang W, Huang Y, Xu Z, et al. The impact of a high-carbohydrate diet on the cognitive behavior of mice in a low-pressure, low-oxygen environment[J]. Food & Function, 2025, 16(3): 1116-1129.

[23] Pei C, Jia N, Wang Y, et al. Notoginsenoside R1 protects against hypobaric hypoxia-induced high-altitude pulmonary edema by inhibiting apoptosis via ERK1/2-P90rsk-BAD ignaling pathway[J]. European Journal of Pharmacology, 2023, 959: 176065.

[24] Xie L, Wu Q, Huang H, et al. Neuroregulation of histamine of circadian rhythm disorder induced by chronic intermittent hypoxia[J]. European Journal of Pharmacology, 2025: 177662.

[25] Ding Y, Liu W, Zhang X, et al. Bicarbonate-Rich Mineral Water Mitigates Hypoxia-Induced Osteoporosis in Mice via Gut Microbiota and Metabolic Pathway Regulation[J]. Nutrients, 2025, 17(6): 998.

[26] Gu N, Shen Y, He Y, et al. Loss of m6A demethylase ALKBH5 alleviates hypoxia-induced pulmonary arterial hypertension via inhibiting Cyp1a1 mRNA decay[J]. Journal of Molecular and Cellular Cardiology, 2024.

[27] Luan X, Zhu D, Hao Y, et al. Qibai Pingfei Capsule ameliorated inflammation in chronic obstructive pulmonary disease (COPD) via HIF-1 α/glycolysis pathway mediated of BMAL1[J]. International Immunopharmacology, 2025, 144: 113636.

[28] Jiang H, Lu C, Wu H, et al. Decreased cold‐inducible RNA‐binding protein (CIRP) binding to GluRl on neuronal membranes mediates memory impairment resulting from prolonged hypobaric hypoxia exposure[J]. CNS Neuroscience & Therapeutics, 2024, 30(9): e70059.

[29] Chang P, Xu M, Zhu J, et al. Pharmacological Inhibition of Mitochondrial Division Attenuates Simulated High‐Altitude Exposure‐Induced Memory Impairment in Mice: [30] Involvement of Inhibition of Microglia‐Mediated Synapse Elimination[J]. CNS Neuroscience & Therapeutics, 2025, 31(6): e70473.

[30] Liu C, Qu D, Li C, et al. miR‐448‐3p/miR‐1264‐3p Participates in Intermittent Hypoxic Response in Hippocampus by Regulating Fam76b/hnRNPA2B1[J]. CNS Neuroscience & Therapeutics, 2025, 31(2): e70239.

[31] Wu L W, Chen M, Jiang D J, et al. TCF7 enhances pulmonary hypertension by boosting stressed natural killer cells and their interaction with pulmonary arterial smooth muscle cells[J]. Respiratory Research, 2025, 26(1): 202.

[32] Xie L, Wu Q, Huang H, et al. Neuroregulation of histamine of circadian rhythm disorder induced by chronic intermittent hypoxia[J]. European Journal of Pharmacology, 2025: 177662.

[33] Cai S, Li Z, Bai J, et al. Optimized oxygen therapy improves sleep deprivation-induced cardiac dysfunction through gut microbiota[J]. Frontiers in Cellular and Infection Microbiology, 2025, 15: 1522431.

[34] Wang X, Xie Y, Niu Y, et al. CX3CL1/CX3CR1 signal mediates M1-type microglia and accelerates high-altitude-induced forgetting[J]. Frontiers in Cellular Neuroscience, 2023, 17: 1189348.

[35] He Y, Wang Y, Duan H, et al. Pharmacological targeting of ferroptosis in hypoxia-induced pulmonary edema: therapeutic potential of ginsenoside Rg3 through activation of the PI3K/AKT pathway[J]. Frontiers in Pharmacology, 2025, 16: 1644436.

[36] Guo Y, Qin J, Sun R, et al. Molecular hydrogen promotes retinal vascular regeneration and attenuates neovascularization and neuroglial dysfunction in oxygen-induced retinopathy mice[J]. Biological Research, 2024, 57.

[37] Liu L, Zhang J, Song S, et al. Paraventricular nucleus neurons: important regulators of respiratory movement in mice with chronic intermittent hypoxia[J]. Annals of Medicine, 2025, 57(1): 2588664.

[38] Ma Q, Ma J, Cui J, et al. Oxygen enrichment protects against intestinal damage and gut microbiota disturbance in rats exposed to acute high-altitude hypoxia[J]. Frontiers in Microbiology, 2023, 14.

[39] Lan J, Lin J, Guo Y, et al. Sequencing and bioinformatics analysis of exosome-derived miRNAs in mouse models of pancreatic injury induced by OSA[J]. Frontiers in Physiology, 2025, 16: 1712442.

[40] Feng X, Li C, Zhang W, et al. Mechanism of retinal angiogenesis induced by HIF-1α and HIF-2α under hyperoxic conditions[J]. Scientific Reports, 2025, 15(1): 36049.

[41] Yao Y, Chen Y, Li Y, et al. TGM2 Enhances Hypobaric Hypoxia-mediated Brain Injury Via Regulating NLRP3/GSDMD Signaling[J]. Neurochemical Research, 2025, 50(6): 1-11.

[42] Yang A, Guo L, Zhang Y, et al. MFN2-mediated mitochondrial fusion facilitates acute hypobaric hypoxia-induced cardiac dysfunction by increasing glucose catabolism and ROS production[J]. Biochimica et Biophysica Acta (BBA)-General Subjects, 2023: 130413.

[43] Chu H, Jiang W, Zuo N, et al. Astrocyte activation: A key mediator underlying chronic intermittent hypoxia-induced cognitive dysfunction[J]. Sleep Medicine, 2025: 106692.

[44] Xu A, Huang F, Chen E, et al. Hyperbaric oxygen therapy attenuates heatstroke-induced hippocampal injury by inhibiting microglial pyroptosis[J]. International Journal of Hyperthermia, 2024, 41(1): 2382162.

[45] Zhang Z, Zheng X, He Y, et al. Hyperbaric oxygen ameliorates neuroinflammation in heat-stressed BV-2 microglial cells: potential involvement of EAAT2 regulation[J]. International Journal of Hyperthermia, 2025, 42(1): 2583133.

[46] Jinyu F, Huaicun L, Yanfei Z, et al. Nogo-A Protein Mediates Oxidative Stress and Synaptic Damage Induced by High-altitude Hypoxia in the Rat Hippocampus[J]. 2024.

[47] Su L, Ni T, Fan R, et al. An attention to the effect of intravitreal injection on the controls of oxygen-induced retinopathy mouse model[J]. Experimental Eye Research, 2024, 248: 110094.

[48] Xu Y, Xu J, Li J, et al. Interplay of HIF-1α, SMAD2, and VEGF signaling in hypoxic renal environments: impact on macrophage polarization and renoprotection[J]. Renal Failure, 2025, 47(1): 2561784.

[49] Zhang D, Bian W, Gao Z. Impact of Obstructive Sleep Apnea on Endometrial Function in Female Rats: Mechanism Exploration[J]. Nature and Science of Sleep, 2025: 2485-2499.

[50] Zhang N, Wei F, Ning S, et al. PPARγ Agonist Rosiglitazone and Antagonist GW9662: Antihypertensive Effects on Chronic Intermittent Hypoxia-Induced Hypertension in Rats[J]. Journal of Cardiovascular Translational Research, 2024: 1-13.

[51] Zhang Y, Zhang A, Yang J, et al. Hypoxic Mesenchymal Stem Cell Exosome‐Derived SLC25A3 Ameliorates Bronchopulmonary Dysplasia by Modulating Macrophage Polarization and Oxidative Stress[J]. Cell Biochemistry and Function, 2025, 43(12): e70152.

[52] Lan J, Wang Y, Liu C, et al. Genome-wide analysis of m6A-modified circRNAs in the mouse model of myocardial injury induced by obstructive sleep apnea[J]. BMC Pulmonary Medicine, 2025, 25(1): 158.

[53] Zhang L, Liu X, Wei Q, et al. Arginine attenuates chronic mountain sickness in rats via microRNA-144-5p[J]. Mammalian Genome, 2023, 34(1): 76-89.

[54] Wei J, Hu M, Chen X, et al. Hypobaric Hypoxia Aggravates Renal Injury by Inducing the Formation of Neutrophil Extracellular Traps through the NF-κB Signaling Pathway[J]. Current Medical Science, 2023: 1-9.

[55] Zhang L, Li J, Wan Q, et al. Intestinal stem cell-derived extracellular vesicles ameliorate necrotizing enterocolitis injury[J]. Molecular and Cellular Probes, 2025, 79: 101997.

[56] Liao Y, Ke B, Long X, et al. Abnormalities in the SIRT1-SIRT3 axis promote myocardial ischemia-reperfusion injury through ferroptosis caused by silencing the PINK1/Parkin signaling pathway[J]. BMC Cardiovascular Disorders, 2023, 23(1): 582.

[57] Wang M, Wen W, Chen Y, et al. TRPC5 channel participates in myocardial injury in chronic intermittent hypoxia[J]. Clinics, 2024, 79: 100368.

[58] Li J, Ye J. Chronic intermittent hypoxia induces cognitive impairment in Alzheimer’s disease mouse model via postsynaptic mechanisms[J]. Sleep and Breathing, 2024: 1-9.

[59] Binbin L I, Haizhen L I, Houhuang C, et al. Utilizing Hyperbaric Oxygen Therapy to Improve Cognitive Function in Patients With Alzheimer’s Disease by Activating Autophagy-Related Signaling Pathways[J]. Physiological Research, 2025, 74(1): 141.

[60] Han J, Wang L, Wang L, et al. 5-Hydroxytryptamine Limits Pulmonary Arterial Hypertension Progression by Regulating Th17/Treg Balance[J]. Biological and Pharmaceutical Bulletin, 2025, 48(5): 555-562.

[61] Nan L, Kaisi F, Mengzhen Z, et al. miR-375-3p targets YWHAB to attenuate intestine injury in neonatal necrotizing enterocolitis[J]. Pediatric Surgery International, 2024, 40(1): 63.

[62] Liu B, Zheng W, Tang C, et al. Scutellarein-containing novel formula attenuates hypoxia through inhibiting apoptosis[J]. 2025.

*我公司可提供3Q驗證，根據(jù)客戶的特殊應用、特殊需求提供功能定制服務，也可以提供相關(guān)的實驗服務，詳情請聯(lián)系我們。

*此介紹及參數(shù)為產(chǎn)品基礎信息，可能滯后于產(chǎn)品更新，具體參數(shù)請與我司聯(lián)系。